ABSTRACT
An antifungal compound 9, 10-dihydrophenanthrene - 2 - carboxylic acid was isolated from a marine derived bacterium Pseudomonas putida isolated from surface water samples of Karachi fish harbor coast line. The structure was explored using extensive 1D- and 2D-NMR spectroscopic techniques. The compound was found to be active against fungal strains obtained from clinical samples whereas strong activity was noted against Candida albicans with a MIC value of 20microg/ml, as the purified compound showed promising anticandidal activity a multidisciplinary approach is needed to explore further this compound as potential pharmacological lead compound against Candida spp and will add in the global hunt for clinically functional antifungal agents
ABSTRACT
Vitamin D deficiency has been implicated in chronic musculoskeletal pain. This article reviews two cases of improvement/ resolution of chronic pain after vitamin D repletion in a pain practice setting in Lahore. Vitamin D insufficiency is common and its repletion may improve chronic musculoskeletal pain and improve quality of life. In some cases, it may result in complete resolution of symptoms. We observed 521 patients over a period of 1 year, of which 2 patients are described in detail. Written informed consent was taken from the patients to publish this report
ABSTRACT
Background / Purpose: The study was conducted to evaluate the Breast cancer patients with metastasis to different body regions
Aims and Objectives: The primary aim was to highlight the most common site of metastasis and different Sonographic patterns in breast cancer patients at CENAR, Quetta. The secondary aim was to determine the average age of breast carcinoma [Ca] presentation
Material and Methods: A two year retrospective study of breast carcinoma diagnosed and treated at our centre was conducted. 278 patients pathologically proven invasive carcinoma breast were registered at CENAR from 1st January 2010 to December 2011 were analyzed
Results: During the study period, 278 patients were registered as Ca breast patients out of which 109 [39%] patients developed metastasis during or after treatment or initially at registration, majority of the patients were with liver metastasis 46 [42%]patients and most common Sonographic pattern was hypo echoic with 26[57%] patients. Most common age group was 25-40 years with 125[45%] patients, followed by 41-55 years with 97[35%] patients
ABSTRACT
Primary polycythemia [polycythemia vera] is a hematopoeitic stem cell disorder giving rise to proliferation of a clone of hematopoietic precursors leading to an excess production of erythrocytes with thrombocytosis and leukocytosis
The optimum management of polycythemia vera remains elusive. Patients requiring surgery are at increased risk of both perioperative thrombosis and hemorrhage
On one hand, thrombosis can lead to multi organ ischemia and infarction while on the other, bleeding diathesis can lead to profuse perioperative hemorrhage; both posing considerable risk to the patient's health and stress to the anesthesiologist concerned directly with perioperative management of the patient
Hence, management guidelines for polycythemia vera needs to be clearly understood and tailored to each patient individually and appropriate management protocols need to be de Ned accordingly
ABSTRACT
Presence of nodule in the thyroid is a common problem throughout the world, incidence of which varies from region to region. This study was designed to appraise the diagnostic strategy to differentiate between malignant and benign lesions in solitary cold thyroid nodules using technetium-99m MIBI scintigraphy. Forty-nine patients were included in the study. All had cold nodule based on Tc-99m pertechnetate scan.Tc-99m MIBI thyroid scan and FNAC were performed in all the patients. Tc-99m MIBI thyroid scan was performed 20-40 min after intravenous injection of 185-370 MBq of Tc-99m MIBI. Uptake of MIBI in thyroid nodules was compared with that in the surrounding normal thyroid tissue and designation of YY, YN and NN were assigned to each nodule .YY means Intense uptake or uptake more than surrounding normal Thyroid tissue, YN means Uptake is equal or nearly equal to surrounding normal Thyroid tissue and NN means no uptake. FNAC revealed nodular goitre in 29 cases, follicular lesion in 8, cysts and hemorrhage in 10, pleomorph in 2. None of the cystic nodules were YY on MIBI scan, while the follicular lesions showed a variety of MIBI imaging patterns most frequently the YY pattern. None of the follicular lesion showed NN uptake on MIBI scan. In the diagnosis of follicular lesion the sensitivities of YY and YY+YN MIBI uptake patterns were 80% and 100% respectively. The YY+YN MIBI uptake patterns had a negative predictive value of 100% and positive predictive value of 36%, whereas a specificity of 54% was observed. After a cold nodule had been detected using Tc-99m pertechnetate, a second scan with YY or YN MIBI uptake increases the probability that this nodule would be suspicious for malignancy. Having no uptake of Tc-99m MIBI in such nodules very safely excludes the possibility of malignancy. Tc-99m MIBI scintigraphy is a useful method in the differential diagnosis of cold thyroid nodules. High MIBI uptake considerably increases the probability of malignancy and facilitates immediate surgical removal while NN or no uptake actually excludes it. We suggest MIBI scan as a routine diagnostic approach to cold thyroid nodules before fine-needle aspiration cytology
Subject(s)
Humans , Male , Female , Thyroid Nodule/diagnosis , Technetium Tc 99m Sestamibi , Parathyroid NeoplasmsABSTRACT
To evaluate the prevalence, geographical features and disease characteristics of Cancer of Esophagus in patients registered at Centre for Nuclear Medicine and Radiotherapy [CENAR]. From January 1991 to December 2001 832 cases of esophageal cancer were seen at CENAR Hospital Quetta. Only cases confirmed by Histopathology and for whom the esophagus was the primary site of tumor were included in the study. The mean age of the patients was 50 + 13year]. The geographical background and disease characteristics were elaborated, by calculating statistical ratios and percentages of various demographic variables, in different subgroups of patients. Cancer of esophagus is 3 rd commonest tumor [11.3% of total registered cases] and on average, the annual proportion of esophageal cancer constitutes a figure of 11 cases per hundred patients diagnosed at CENAR Hospital. It is third common tumor in male and 4 th common in female, with Male to female ratio of 1.37. It is about 1.33 times more common in Balochistan than in Afghanistan. Naswar and beetle nut chewing [31%], malnutrition [56%] and Alcohol [13%] were among the common risk factors present in this study population. About 90% of the cases were of Squamous cell variety and 85% of the patients were diagnosed when disease has progressed to stage 3/4 and upto 60% cases involve lower third of esophagus. Forty percent of the patients were in 4th decade of life at time of diagnosis. The areas that surround CENAR Hospital in Balochistan Province seem to be a high-risk belt for esophageal cancer. It is also common in Afghanistan and Peshawar. Naswar and beetle nut chewing along with malnutrition and alcohol might be important contributory risk factors
Subject(s)
Humans , Male , Female , Esophageal Neoplasms/diagnosis , Esophageal Neoplasms/pathology , PrevalenceABSTRACT
Objective: The objective was to determine the frequency of different blood groups in the region, which would not only help in blood transfusion services but also eliminate the risk of erythroblastosis fetalis in the neonates
Method: Blood group determination was carried out over a period of 16 months from January 2002 to April 2003, and encompassed 2581 subjects, in which 57.09% were male and 42.9% female, these were categorized by their groups, A, B, AB, and O
Results: The percentage of these groups were 31.03% [A], 36.23% [B], 7.67% [AB], and 25.07% [O]. The Rh positive and negative distribution in the studied population was 89.23% and 10.77% respectively
Conclusion: The studied population exhibited a predominance of group B, in the order of B>A>O>and AB, as well as Rh positive antigen for both male [90.26%] and female [87.98%] subjects within the population, with Rh negative men and women being 9.74% and 12.02% respectively